Lower-limb Osteoarthritis is a degenerative disease that affects the joints in the lower extremities, such as the hips, knees, and feet. It occurs when the protective cartilage that cushions the ends of the bones wears down over time, leading to pain, stiffness, and reduced mobility. Osteoarthritis is one of the most common forms of arthritis and Lower-limb OA specifically, affects millions worldwide.